A recent study was published in June 2018 documenting the difference in immune response from vaccination based on age. "We particularly noticed that the number of low and non-responders to booster vaccinations increased with age." pg2.

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"Vaccine-specifc antibody titres were signifcantly lower in elderly participants and 47% of them were non- or low responders after the two doses of the vaccine neo-antigen." pg1.

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              The study can be downloaded here