MMR
Dosage:
“For Children and Adolescents
The dosage for both MMR and MMRV is 0.5 mL. Both vaccines are administered by the subcutaneous route.
The minimum age for both MMR and MMRV is 12 months of age.
For Adults
The dosage for MMR vaccine is 0.5 mL by the subcutaneous route. “
https://www.cdc.gov/vaccines/vpd/mmr/hcp/administering-mmr.html
Travel doses and outbreak recommendations:
The cdc recommends travellers vaccinate their children starting at 6 months before departure on vacation. Local health authorities like weve seen recommended and forced in Brooklyn, NY also insist on starting the MMR injections at 6 months. Contrary to these recommendations, the MMR vaccine has not been tested for safety or effectiveness in that population:
"Local health authorities may recommend measles vaccination of infants between 6 to 12 months of age in outbreak situations. This population may fail to respond to the components of the vaccine. Safety and effectiveness of mumps and rubella vaccine in infants less than 12 months of age have not been established."
Is the MMR safe?
Out of a case series of 271,495 kids after their 12 month vaccines, 1 in 168 children visit the hospital emergency room. Also 20 ferbile seizures out of every 100,000 infants after their 12m vaccines.
Out of studying 184,312 kids after they got their 18 month vaccines, 1 in 730 children visit the hospital emergency room.
"There are significantly elevated risks of primarily emergency room visits approximately one to two weeks
following 12 and 18 month vaccination."
Why infants are susceptible at a younger age than before:
“In addition, measles susceptibility of infants younger than 1 year of age may have increased. During the 1989–1991 measles resurgence, incidence rates for infants were more than twice as high as those in any other age group. The mothers of many infants who developed measles were young, and their measles immunity was most often due to vaccination rather than infection with wild virus. As a result, a smaller amount of antibody was transferred across the placenta to the fetus, compared with antibody transfer from mothers who had higher antibody titers resulting from wild-virus infection. The lower quantity of antibody resulted in immunity that waned more rapidly, making infants susceptible at a younger age than in the past.”
https://www.cdc.gov/vaccines/pubs/pinkbook/meas.html
On the antibody level difference:
“I was infected naturally with measles. Is it true that after being naturally infected with measles that I probably have higher frequencies of memory, immune cells, b and t cells, than does someone who was vaccinated? Yes I do, it is true. The virus reproduced 1000 of times in me, not the 10 or 20 times when you get the vaccine, so so I have a much greater immune response its true.
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Paul Offit
https://www.youtube.com/watch?v=c9txqfadfd0
The future of measles in a highly immunized population:
“The results of this study suggest that measles elimination in the United States has been achieved by an effective immunization program aimed at young susceptibles combined with a highly, naturally immunized adult population. However, despite short-term success in eliminating the disease, long-range projections demonstrate that the proportion of susceptibles in the year 2050 may be greater than in the prevaccine era. Present vaccine technology and public health policy must be altered to deal with this eventuality.”
https://www.ncbi.nlm.nih.gov/pubmed/6741921
Outbreaks and shedding:
Vaccine strain measles can be difficult to recognize and distinguish from wild measles.
"While the current measles vaccine used in the USA and many other countries is safe and effective, paradoxically in the unique case of measles, it appears to insufficiently induce herd immunity in the population. This relates to a combination of factors including: higher than observed rates of primary and secondary vaccine failure in clinical practice versus that seen in clinical trials"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570049/
"Recent measles outbreaks in the Canadian provinces of Alberta and British Columbia have emphasized the need for rapid differentiation of vaccine reactions (18, 19) from reactions to infection with the wild-type virus. During the measles outbreak in California in 2015, a large number of suspected cases occurred in recent vaccinees (3). Of the 194 measles virus sequences obtained in the United States in 2015, 73 were identified as vaccine sequences"
https://jcm.asm.org/content/55/3/735
Measles vaccine strain shedding in Ontario, Canada 2015
"2 had received measles-containing vaccine before onset of symptom" "ML identified wild-type virus in 17 of 33 persons and genotype A vaccine strain by conventional N-450 sequencing in the remaining 16. In addition, NML rapidly detected vaccine strain in 15 of these 16 persons by using a laboratory-developed rRT-PCR specific for measles vaccine strain"
Vaccine strain measles shed in urine
Vaccinated child gets vaccine strain measles 11 days after vaccination
http://www.fox2detroit.com/news/let-it-rip/the-vaccination-debate-amid-measles-outbreak
Vaccinated child gets vaccine strain measles.
https://thejewishnews.com/2019/04/12/no-measles-outbreak-in-ann-arbor-after-all/
12 year old boy (DiGeorge Patient) on a TNF Inhibitor received the MMR vaccine 10 days prior to being diagnosed with confirmed, vaccine strain measles.
13 month old immunocompetent child diagnosed with vaccine strain measles after vaccination.
Examples of measles outbreaks among previously vaccinated populations:
Outbreak among the twice vaccinated in New York, showing vaccine failure.
https://www.ncbi.nlm.nih.gov/pubmed/24585562
Outbreak among a full immunized secondary school population in Texas. 99% of kids had vaccination records against measles, and only 4.1% of students lacked detectable antibodies.
“outbreaks of measles can occur in secondary schools, even when more than 99 percent of the students have been vaccinated and more than 95 percent are immune”
https://www.ncbi.nlm.nih.gov/pubmed/3821823
Outbreak among soldiers who all had 2 or 3 doses of the MMR vaccine, “the high IgG avidity suggests secondary vaccine failure”.